To bypass GHB restriction laws, home synthesis kits were introduced to transform GBL and/or 1,4-B into GHB. Mater. Hong Kong SAR: GBL is a dangerous drug controlled under Schedule 1 of the Dangerous Drugs Ordinance, Cap.134 (with exemption clause at Paragraph 16D). [20] GBL overdose can cause irrational behaviour, severe sickness, coma and death.[21]. [7][40], United States: GBL is regulated as a List I controlled chemical. Save this search to receive email alerts and notifications when new items are available. Molecular Weight 86.09 . Although recently passed legislation to enter into force on 1 April 2011 will make it possible to handle narcotics for industrial purposes will enable GBL and 1,4-Butanediol to be classified as controlled substances. Schedule VI of the "Controlled Drugs and Substances Act" requires vendors to collect information regarding purchases of GBL. The related compound caprolactone can be used to make a polyester in this manner. [4], In the laboratory, it may also be obtained via the oxidation of tetrahydrofuran (THF), for example with aqueous sodium bromate. @p0ly 394461 wrote:. [4], Butyrolactone, with its wide liquid range, chemical stability and high dielectric constant, is used in some batteries but primarily is found in electrolytic capacitors as the organic solvent. Reference substance name: γ-butyrolactone EC Number: 202-509-5 EC Name: γ-butyrolactone CAS Number: 96-48-0 … A license is mandatory for the manufacture, processing, reworking, importing, distribution of GBL.[38]. People use it as medicine. Date HS Code Description Origin Country Port of Discharge Unit Quantity Value (INR) Per Unit (INR) Nov 07 2016: 29321990: GBL (GAMMA-BUTYROLACTONE) ISO TANK CONTAINERS Its trafficking is limited, and non-licensed selling, buying or any other use is punishable by imprisonment up to 20 years. Please update this article to reflect recent events or newly available information. 36th ECDD (2014) Agenda item 4.3 Gamma‐butyrolactone (GBL) Page 10 of 28 E. Chemical description GBL is a lactone. GBL is a prodrug of GHB and its recreational use comes entirely as a result of this. MDL number MFCD00005386. [Tianqi Niu, Jing Lu, Rahim Munir, Jianbo Li, Dounya Barrit, Xu Zhang, Hanlin Hu, Zhou Yang, Aram Amassian, Kui Zhao, and Shengzhong (Frank) Liu: "Stable High-Performance Perovskite Solar Cells via Grain Boundary Passivation", Adv. Buy Gamma-butyrolactone GBL For Sale Online From The Best Vendors. gamma-butyrolactone-powder (?-butyrolactone or GBP) is a hygroscopic compound with a weak characteristic odor and is soluble in water.gamma-butyrolactone-powder for sale,gamma butyrolactone ebay,price,australia,suppliers. γ-Butyrolactone (GBL) is a hygroscopic colorless, water-miscible liquid with a weak characteristic odor.It is the simplest 4-carbon lactone.It is mainly used as an intermediate in the production of other chemicals, e.g. Israel: GBL was classified as a proscribed substance from 2007. Australia: GBL is not classified as a drug but as a health-endangering substance. [39], United Kingdom: Because of their legitimate uses, regulation 4B of the 2001 regulations makes it lawful to import, export, produce, supply, offer to supply or possess GBL and 1,4-BD. γ-butyrolactone(GBL) CAS 96-48-0,Application: r-butyrolactone is an important organic chemical raw material, which is widely used in the pharmaceutical, pesticide, petrochemical and other industries_OKCHEM Gamma Butyrolactone Price - Select 2021 high quality Gamma Butyrolactone Price products in best price from certified Chinese Gamma Sterile Gauze Swabs manufacturers, Gamma Oryzanol suppliers, wholesalers and factory on Made-in-China.com It is a prodrug for the illegal substance GHB, which means that the body naturally converts it into GHB. Often mixtures of GBL and DMSO yield best results. Copyright © 1995-2021 eBay Inc. All Rights Reserved. Light to moderate users often experience insomnia and sleep-related problems, whereas heavy, prolonged use can cause severe withdrawal symptoms similar to Benzodiazepine withdrawal syndrome (BWS). It is miscible with water, alcohols, ketones, esters and aromatic hydrocarbons. for all available grades of Gamma butyrolactone in the world. When treated with a non-nucleophilic base, such as lithium diisopropylamide, GBL undergoes deprotonation alpha to the carbonyl. It is mainly used as an intermediate in the production of other chemicals, e.g. Gamma-Butyrolactone, or GBL, is a chemical that is used as a precursor in the illicit manufacture of the schedule I controlled substance gamma-hydroxybutyric acid, or GHB. Compositions . Beilstein/REAXYS Number 105248 . [citation needed]. These gamma butyrolactone are of Grade A quality and come in a liquid-like appearance. [15][16] Animals which lack these enzymes exhibit no effect from GBL. Boundary Composition(s) open all close all. See each listing for international postage options and costs. [33], Canada: GBL is a Controlled Substance under Schedule VI of the "Controlled Drugs and Substances Act" in Canada. Russia: GBL has been classified as a psychotropic substance since 22 February 2012. Gamma-Butyrolactone ; Tetrahydro-2-furanone . Empirical Formula (Hill Notation) C 4 H 6 O 2. Compound gamma-Butyrolactonewith free spectra: 53 NMR, 21 FTIR, 3 Raman, 2 Near IR, and 25 MS. γ-Butyrolactone (GBL) is a hygroscopic colorless, water-miscible liquid with a weak characteristic odor. Ammonia gives pyrrolidone. Due to its property of being a prodrug of GHB which increases sleep related growth hormone (GH) secretion,[18] GBL was sold as a nutritional supplement after the scheduling of GHB, under the names Revivarant and Renewtrient[19] until they were banned by the Genuine Chem Sales is a top-notch online store from where you can buy Gamma-butyrolactone GBL at cheap price.We are always available for you here to help you buy Gamma-butyrolactone GBL … Sweden: GBL is not classified as a drug but as a health-endangering substance. You will get your order on time and you can track it at every step of the way. Recently GBL has become an important solvent for the development of organic perovskites (such as Methylammonium lead halide), novel solar cell materials that can be processed from solution. gamma-BUTYROLACTONE: ICSC: 1020: 1,4-Butanolide Butyric acid lactone Tetrahydro-2-furanone Dihydro-2(3H)-furanone: May 2018: CAS #: 96-48-0 EC Number: 202-509-5 ACUTE HAZARDS PREVENTION FIRE FIGHTING; FIRE & EXPLOSION: Combustible. Although legislation to enter into force on 1 April 2011 will make it possible to handle narcotics for industrial purposes will enable GBL and 1,4-Butanediol to be classified as controlled substances. PubChem Substance ID 24891553. EC Number 202-509-5. [29], Frequent use of GHB/GBL, even when taken long-term and in moderate doses, does not appear to cause significant physical dependency in the majority of its users. [32] This is where the user has become tolerant to the effects of the drug, increasing the dosage and frequency of dosage simply to avoid withdrawal symptoms. The Act also prohibits the import and export of GBL into or out of Canada classifying it as either an indictable offense punishable with up to 10 years in prison or an offense punishable on summary conviction liable to imprisonment for up to eighteen months. It is possible for oral ingestion of GBL to cause nausea and other similar problems, possibly more so than with GHB. Except where a person does so knowing or believing that they will be used for the purpose of human ingestion. As a lactone, GBL is hydrolyzed under basic conditions, for example in a sodium hydroxide solution into sodium gamma-hydroxybutyrate, the sodium salt of gamma-hydroxybutyric acid. [35], Netherlands: GBL is unlike GHB not listed in the narcotics law,[36] but its distribution is controlled. We provide only the purist quality product, direct from our European lab partners. With the CAS registry number 96 … FDA. gamma-butyrolactone powder for sale,an industrial solvent & antecedent of pyrrolidones,& health additive.gamma butyrolactone ebay,price,australia,suppliers Amounts shown in italicised text are for items listed in currency other than Euros and are approximate conversions to Euros based upon Bloomberg's conversion rates. GBL is not active in its own right; its mechanism of action stems from its identity as a prodrug of GHB. 72 matches found for gamma-butyrolactone . Gamma-Butyrolactone Liquid GBL (gamma butyrolactone, ‘geeb’) is a clear liquid solvent. Avoid Getting Scammed. Search term: "gamma-butyrolactone" Compare Products: Select up to 4 products. Overview Information Gamma butyrolactone is a chemical. [4] In humans GBL acts as a prodrug for γ-hydroxybutyric acid (GHB), and it is used as a recreational CNS depressant with effects similar to barbiturates. Maximised Survey-derived Daily Intakes (MSDI-EU): 110.00 (μg/capita/day) Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). As a result of this sedation it can cause unconsciousness. Under acidic conditions it forms an equilibrium γ-Butyrolactone. Gives off irritating or toxic fumes (or gases) in a fire. Number of bids and bid amounts may be slightly out of date. Reaction with methylamine gives NMP. Information for gamma-butyrolactone 96-48-0 including gamma-butyrolactone CAS NO 96-48-0, gamma-butyrolactone Suppliers, gamma-butyrolactone Manufacturers, related products of gamma-butyrolactone. [8] An alternative route proceeds from GABA using the Sandmeyer reaction.[9]. Many harm reduction organisations suggest never mixing the two drugs as a result. We do not import from china, all our GBL is 100% Pharmaceutical Grade! γ-Butyrolactone ReagentPlus ®, ≥99% Synonym: γ-Hydroxybutyric acid lactone, 4-Hydroxybutyric acid lactone, GBL, gamma-Butyrolactone CAS Number 96-48-0. Gamma-Butyrolactone ( γ – butyrolactone or GBL ) is a hygroscopic colorless liquid with a weak characteristic odor which is soluble in water. It is also used as a solvent in lotions and some polymers. [10][12], Butyrolactone is principally a precursor to other chemicals. In humans GBL acts as a prodrug for γ-hydroxybutyric acid (GHB), and it is used as a recreational CNS depressant with effects similar to barbiturates [5][6] This finding indicates that GBL is a naturally occurring component in some wines and may be present in similar products. Solubility is limited in aliphatic and cycloaliphatic hydrocarbons. Shop with confidence. [41], Except where otherwise noted, data are given for materials in their. For more recent exchange rates, please use the. In recent years, an increase of GBL consumption has been observed due to the prohibition of GHB. The gamma-Butyrolactone is an organic compound with the formula C 4 H 6 O 2.The IUPAC name of this chemical is oxolan-2-one. It is hydrolyzed under basic conditions, for example in a sodium hydroxide solution into sodium gamma-hydroxybutyrate, the sodium salt of gamma-hydroxybutyric acid. GBL can be found in cheese flavourings but typically results in a content of 0.0002% GBL in the final foodstuff. It’s like alcohol, warm fuzzy alcohol like feeling but without the drunk stupidity… well instead you just completely KO. [15] GBL is more lipophilic (fat soluble) than GHB, and so is absorbed faster and has higher bioavailability. methyl-2-pyrrolidone. *Please select more than one item to compare. Gamma butyrolactone (GBL) is a hygroscopic, water soluble oily liquid,produced by International Diol Company (IDC), an affiliate of Sipchem from Oct. 2014. [26] When combined with alcohol the increased sedation and risk of vomiting results in a high risk of fatality. [7], γ-Butyrolactone is produced industrially by dehydrogenation of 1,4-butanediol at a temperature of 180–300 °C and atmospheric pressure in the presence of a copper catalyst. In acidic water, a mixture of the lactone and acid forms coexist in an equilibrium. Description. GBL is a good solvent for the precursor salts such as lead halides and methylammonium iodide or formamidinium iodide. This solution chemistry is strongly dependent upon solution pH, as well as other factors, and is … For those users who do report withdrawal symptoms upon quitting the use of GHB/GBL, symptoms seem to depend on the dosage and the length of time the drug was used. A milliliter of pure GBL metabolizes to the equivalent 1.65 g of NaGHB, the common form, so doses are measured in the single milliliter range, either taken all at once or sipped over the course of a night. Posted on April 19, 2013 January 17, 2014. The ring-opening polymerization of butyrolactone gives polybutyrolactone. GBL is a common solvent and reagent in chemistry as well as being used as a flavouring, as a cleaning solvent, as a superglue remover, and as a solvent in some wet aluminium electrolytic capacitors. This differs significantly from GHB, which is described as having a decidedly "salty" taste. i kept redosing hoping the effects would get stronger but they do not, all that happens is the euphoria stays the same and you get more and more tired. Possession is not illegal but may be punished according to the Medicines Act, when intended to be sold for human consumption or synthesis of GHB. It is the simplest 4-carbon lactone. Because of these pharmacokinetic differences, GBL tends to be more potent and faster-acting than GHB, but has a shorter duration; whereas the related compound 1,4-butanediol (1,4-B) tends to be slightly less potent, slower to take effect but longer-acting than GHB.[17]. [27][28], There have been news reports of several deaths associated with GBL, usually in combination with alcohol or other depressants. The concentration detected was approximately 5 μg/mL and was easily observed using a simple extraction technique followed by GC/MS analysis. [10][11] It is claimed that poly(GBL) is competitive with commercial biomaterial poly(4-hydroxybutyrate), or P4HB. 2018, 1706576. This page was last updated: 13-Feb 11:46. View detailed Import data, price, monthly trends, major importing countries, major ports of gamma butyrolactone under HS Code 29322090 GHB has biphasic effects, a euphoric effect at low doses (the reason for the term liquid ecstasy), and a sedative effect[25] at higher doses. [14] GBL is an alternative to the more toxic solvent dimethylformamide that was used in the earlier stages of the development of the perovskite solar cell. About product and suppliers: Alibaba.com features the best in class gamma butyrolactone that are highly pure, colorless and safe to use. Find great deals on eBay for gamma-butyrolactone. [22], Due to the fact that those with limited chemistry knowledge can make GBL with easy to get precursors, it has become quite popular among young people in French nightclubs.[23][24]. [30] Management of GBL dependence involves considering the person's age, comorbidity and the pharmacological pathways of GBL.[31]. Gamma-butyrolactone (GBL) is a precursor in the manufacture of gamma-hydroxybutyric acid (GHB). Possession is not illegal, but may be punished according to the Medicines Act, when intended to be sold for human consumption or synthesis of GHB. ], Gamma-Hydroxybutyric_acid § Sports_and_athletics, Ullmann's Encyclopedia of Industrial Chemistry, "A Change to the Misuse of Drugs Act 1971 : Control of GBL, 1,4-BD, BZP and related piperazine compounds, a further group of anabolic steroids and 2 non-steroidal agents, synthetic cannabinoid receptor agonists and oripavine", "New, fully recyclable and biodegradable plastic could change the world", "Gamma-butyrolactone (GBL) Pre-Review Report", "Simultaneous stimulation of slow-wave sleep and growth hormone secretion by gamma-hydroxybutyrate in normal young Men", "Erowid GHB vault: FDA Warning about Gamma Butyrlactone", "USDOJ: U.S. Department of Justice Archive National Drug Intelligence Center", "Drogue : " L'interdiction de vente au public du GBL n'a rien changé à la consommation, "Coroner's 'Russian roulette' warning over GBL party drug", "GBL drug death identified by UK doctors", GHB addiction, GHB physical n psychological dependency levels, Crew 2000 | GHB/ GBL Dependancy | | Drugs information, advice & support, Scotland, UK, LAW AND JUSTICE LEGISLATION AMENDMENT (SERIOUS DRUG OFFENCES AND OTHER MEASURES) ACT 2005 NO. Gamma-Butyrolactone Liquid (γ-butyrolactone or GBL) is a hygroscopic compound with a weak characteristic odor and is soluble in water.gamma-butyrolactone-powder for sale,gamma butyrolactone ebay,price,australia,suppliers GBL Wheel Brite provides a tracking number on every Gamma-butyrolactone (GBL) wheel cleaner order and we only use express shipping services. The gamma butyrolactone available here can be used in a variety of distinct pharmaceutical, organic and other chemical processes. [34] It is not illegal for an individual to possess GBL in Canada. In aqueous solution, GBL undergoes a hydrolysis reaction and exists in equilibrium with GHB. Description Gamma-Butyrolactone (GBL) is a colorless liquid free of suspended matter. Any person who is found to have in his possession of it not in accordance with this Ordinance can be liable, on conviction upon indictment, a fine of HK$1,000,000 and to imprisonment for 7 years. . Gamma-Butyrolactone (GBL) State Form: liquid. GBL has a distinctive taste and odour, described as being comparable to stale water, synthetic melon aroma or burnt plastic. In many people, quitting or temporarily abstaining from use of the drugs is achieved with minimal or no difficulty. The resulting reverts to the monomer by thermal cracking. In this capacity, it is frequently mixed with a small ratio of ethylene glycol, "9:1" being common, to vary internal resistivity.[13]. These compounds then may go on to form the polymer poly(4-hydroxybutyrate) as well as the dimer 1,6-Dioxecane-2,7-dione. As a GHB analog, it is also treated as a controlled substance under Schedule I of the Controlled Substances Act if intended for human consumption. If taken undiluted by mouth, GBL can cause esophageal and gastro-intestinal irritation. GBL is rapidly converted into GHB by paraoxonase (lactonase) enzymes, found in the blood. It is further claimed that poly(GBL) is cheaper to make than P4HB, although both are bio-derived. Upon iv injection, the 5-minute value was 85 ug/mL, whereas gamma-butyrolactone was no longer detectable after 15 minutes. Constituent 1. Recommendation for gamma-butyrolactone usage levels up to: 0.5000 % in the fragrance concentrate. However, when consumed in excessive amounts with a high frequency of dosing, physical and psychological dependence can develop. [4], The yield of this process is approximately 95%. GHB/GBL users can adopt a '24/7' dosing regime. GBL has been found in extracts from samples of unadulterated wines. [37], Poland: GBL is classified as a drug. methyl-2-pyrrolidone. Advanced Search | Structure Search. Safety Gamma-Butyrolactone … The purification takes place with a liquid-gas-phase extraction. 129, 2005 - SCHEDULE 1, Controlled Drugs and Substances Act (S.C. 1996, c. 19), section 7c of chapter B of part A of the 1st appendix of the Dangerous Drugs Act 1973, "wetten.nl - Regeling - Opiumwet - BWBR0001941", https://www.gif.gov.pl/pl/decyzje-i-komunikaty/komunikaty/874,KOMUNIKAT-Nr-32016-GLOWNEGO-INSPEKTORA-FARMACEUTYCZNEGO.html, Socialutskottets betänkande 2010/11:SoU5 - Riksdagen, Information Bulletin: GHB Analogs; GBL, BD, GHV, and GVL, Serotonin antagonists and reuptake inhibitors, https://en.wikipedia.org/w/index.php?title=Gamma-Butyrolactone&oldid=995851065, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Wikipedia articles in need of updating from January 2020, All Wikipedia articles in need of updating, Articles with unsourced statements from August 2009, Creative Commons Attribution-ShareAlike License, This page was last edited on 23 December 2020, at 06:08. Germany: GBL is not listed in the narcotics law, but its distribution is controlled. 4. The blood gamma-butyrolactone levels was 63 ug/mL 5 minutes after ip injection, while it was 22.5 ug/mL at 60 minutes; however, only 2 out of 6 animals had levels above the limit of detection at 60 minutes. - Full REACH registration till 1000 metric tons annually - Correct labeling and packaging conform REACH-CLP - Always an eSDS in the native language with our shipments - Many years of experience and know how